The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Melanocins A, B and C, New Melanin Synthesis Inhibitors Produced by Eupenicillium shearii
I. Taxonomy, Fermentation, Isolation and Biological Properties
JONG-PYUNG KIM, BYOUNG-KWON KIM, BONG-SIK YUN, IN-JA RYOO, CHOONG HWAN LEE, IN-KYOUNG LEE, WON-GON KIM, SANGKU LEE, YU-RYANG PYUN, ICK-DONG YOO
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2003 Volume 56 Issue 12 Pages 993-999

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Abstract

New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0nM and MIC value of 0.9μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.

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