Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus niveus LU 9575 II. Structure Elucidation

ALEXANDRA HÖLTZEL; DIETMAR G. SCHMID; GRAEME J. NICHOLSON; PHILIPP KRASTEL; AXEL ZEECK; KLAUS GEBHARDT; HANS-PETER FIEDLER; GÜNTHER JUNG

doi:10.7164/antibiotics.57.715

Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus niveus LU 9575

II. Structure Elucidation

ALEXANDRA HÖLTZEL, DIETMAR G. SCHMID, GRAEME J. NICHOLSON, PHILIPP KRASTEL, AXEL ZEECK, KLAUS GEBHARDT, HANS-PETER FIEDLER, GÜNTHER JUNG

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JOURNAL FREE ACCESS

2004 Volume 57 Issue 11 Pages 715-720

DOI https://doi.org/10.7164/antibiotics.57.715

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Abstract

The structures of new cytochalasan fungal metabolites aspochalamins A-D have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins A-D consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z, 13E, 19E-triene-1, 21-dione.

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