Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Successful Treatment of Cerebral Aspergillosis with a High Oral Dose of Itraconazole after Excisional Surgery
Tomihiro IMAIToshiyuki YAMAMOTOShingo TANAKAMotoi KASHIWAGISusumu CHIBAHiroyuki MATSUMOTOTeiji UEDE
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JOURNAL FREE ACCESS

1999 Volume 38 Issue 10 Pages 829-832

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Abstract

We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity. The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).
(Internal Medicine 38: 829-832, 1999)

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