Antibody-mediated Insulin Resistance Treated by Cessation of Insulin Administration

Kazuo HARA; Kazuyuki TOBE; Yasuko UCHIGATA; Makoto NAKAZONO; Kazuki YASUDA; Yasuo TERAUCHI; Yasuhiko IWAMOTO; Yasuo AKANUMA; Satoshi KIMURA; Takashi KADOWAKI

doi:10.2169/internalmedicine.39.143

Kazuo HARA, Kazuyuki TOBE, Yasuko UCHIGATA, Makoto NAKAZONO, Kazuki YASUDA, Yasuo TERAUCHI, Yasuhiko IWAMOTO, Yasuo AKANUMA, Satoshi KIMURA, Takashi KADOWAKI

Author information

Kazuo HARA
the Institute for Diabetes Care and Research, Asahi Life Foundation
the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
Kazuyuki TOBE
the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
Yasuko UCHIGATA
the Diabetes Center, Tokyo Women's Medical College
Makoto NAKAZONO
the Forth Department of Internal Medicine, Hachinohe City Hospital
Kazuki YASUDA
the Institute for Diabetes Care and Research, Asahi Life Foundation
the Department of Medical Genetics, Chiba University, School of Medicine
Yasuo TERAUCHI
the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
Yasuhiko IWAMOTO
the Diabetes Center, Tokyo Women's Medical College
Yasuo AKANUMA
the Institute for Diabetes Care and Research, Asahi Life Foundation
Satoshi KIMURA
the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
Takashi KADOWAKI
the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo

Keywords: anti-insulin antibody, Scatchard analysis

JOURNAL FREE ACCESS

2000 Volume 39 Issue 2 Pages 143-145

DOI https://doi.org/10.2169/internalmedicine.39.143

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Abstract

A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 μU/ml, but a high liter of total insulin (about 3, 000 μU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.
(Internal Medicine 39: 143-145, 2000)

Corresponding author

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