The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference
Tsutomu SuzukiYoshinao ShiozakiYoshikazu MasukawaMiwa MisawaHiroshi Nagase
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JOURNAL FREE ACCESS

1992 Volume 58 Issue 4 Pages 435-442

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Abstract

Effects of buprenorphine, U-50, 488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the cocaine-induced place preference. Furthermore, the kappa-receptor agonist U-50, 488H and the mu-receptor antagonist naltrexone both antagonized the cocaine preference. U-50, 488H or naltrexone alone induced a place aversion in a dose-dependent manner. However, the cocaine-induced conditioned place preference was not blocked by lithium chloride, although the latter induced a conditioned place aversion, indicating that the antagonism of cocaine-induced place preference by U-50, 488H or naltrexone does not result from a functional antagonism. These results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference.

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